Interplay of synaptic and backpropagating signals in neurogliaform dendrites: ex vivo data, NEURON files, and python code used for computational modelling

<p dir="ltr">Supporting files for the preprint:</p><p dir="ltr"><br></p><p dir="ltr">Interplay of synaptic and backpropagating signals in neurogliaform dendrites</p><p dir="ltr">Simonas Griesius1*, Amy Richardson1, Marion Mercier1, Dimitri M Kullmann1*</p><p dir="ltr"><br></p><p dir="ltr">1 Department of Epilepsy, UCL Queen Square Institute of Neurology,</p><p dir="ltr">University College London, London, WC1N 3BG, United Kingdom</p><p dir="ltr"><br></p><p dir="ltr">*Corresponding author</p><p dir="ltr"><br></p><p dir="ltr">Correspondance: s.griesius@ucl.ac.uk or d.kullmann@ucl.ac.uk</p><p dir="ltr">DOI: https://doi.org/10.1101/2025.09.10.675107</p><p dir="ltr"><br></p><p>*********************************************************************</p><p>*********************************************************************</p><p dir="ltr"><br></p><p dir="ltr"><br></p><p dir="ltr">Repository contains ex vivo data (LTP induction, backpropagating action potentials and dendritic calcium fluorescence)</p><p dir="ltr"><br></p><p dir="ltr">Repository also contains files necessary to recreate the simulations used in the paper.</p><p dir="ltr"><br></p><p>*********************************************************************</p><p>*********************************************************************</p><p dir="ltr"><br></p><p dir="ltr"><br></p><p dir="ltr">Install the NEURON simulation environment.</p><p dir="ltr"><br></p><p dir="ltr">Compile the .mod and .hoc files</p><p dir="ltr"><br></p><p dir="ltr">Run the Jupyter notebooks.</p><p dir="ltr"><br></p><p dir="ltr">Notes books may have key lines of code at the top that can be comment and uncomment</p><p dir="ltr">to specify important simulations settings - such as presence or absence of induced somatic</p><p dir="ltr">action potential spikes or synaptic input.</p><p dir="ltr"><br></p><p dir="ltr">Notebooks:</p><p dir="ltr"><br></p><p dir="ltr">asynch_and_nearsynch_uncaging_simulation.ipynb - fig 2, fig 8</p><p dir="ltr">tbs_ltp.ipynb - fig 4</p><p dir="ltr">somatic_action_potential_spikes_and_synaptic_input_dendrite_26.ipynb - fig 5, 7</p><p dir="ltr">stdp_calcium.ipynb - fig 9</p><p dir="ltr"><br></p><p dir="ltr">heatmap_plot.ipynb - reads a .csv to make heatmaps used in the paper. </p>