<b>Alpha B crystallin (CRYAB) Degradome Foundation Atlas</b>

<p dir="ltr">This open-access dataset presents Version 1 of the <b>alpha B </b><b>Crystallin (CRYAB) Degradome Foundation Atlas</b>, a curated <b>proteolytic peptide resource</b> designed to advance translational research in protein aggregation myopathies and cardiomyopathies.</p><p dir="ltr">The atlas integrates proteolytic fragments derived from human <b>CRYAB</b>, including wild-type and mutant (<b>R120G</b>) implicated in desmin-related myopathy and CRYAB associated cardiomyopathy [1]. By systematically mapping and annotating these cleavage products, the dataset provides a foundational framework for understanding proteostasis imbalance, aggregation dynamics, and degradation pathways in CRYAB linked disease(s).</p><p dir="ltr">These data are particularly relevant for researchers studying molecular chaperone dysfunction, oxidative and reductive stress, and protein misfolding mechanisms in striated muscle and cardiac tissue. The atlas enables cross-referencing of peptide signatures with mutation type, tissue specificity, and experimental treatment response, supporting biomarker discovery, mechanistic modelling, and therapeutic target validation.</p><p dir="ltr">Each peptide entry includes detailed information on cleavage position and biochemical properties. The dataset is distributed as a tab-delimited ASCII (.txt) file for seamless integration with bioinformatics and statistical workflows.</p><h4><b>Reproducibility</b></h4><p dir="ltr">All datasets can be regenerated using open-source tools (Python, BLAST, SAS). Fully documented scripts are available [3] to ensure transparency, reproducibility, and adaptability across computational environments, following the methodology described in [2].</p><h4><b>References</b></h4><p dir="ltr">[1] Rajasekaran NS, Connell P, Christians ES, Yan L-J, Taylor RP, Orosz A, <i>et al.</i><br><i>Human αB-Crystallin Mutation Causes Oxido-Reductive Stress and Protein Aggregation Cardiomyopathy in Mice.</i><br><i>Cell.</i> 2007;130(3):427–439. doi:10.1016/j.cell.2007.06.044</p><p dir="ltr">[2] Petzold A. <i>Proteolysis-Based Biomarker Repertoire of the Neurofilament Proteome.</i><br><i>J Neurochem.</i> 2025 Mar;169(3):e70023. doi:10.1111/jnc.70023. PMID: 40066701; PMCID: PMC11894590.</p><p dir="ltr">[3] doi:10.5522/04/25689378</p><p dir="ltr"><br></p>