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Biomedical consequences of elevated cholesterol-containing lipoproteins and apolipoproteins on cardiovascular and non-cardiovascular outcomes

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This directory contains the data necessary to generate the results described 

in the manuscript: 'Biomedical consequences of elevated cholesterol-containing 

lipoproteins and apolipoproteins on cardiovascular and non-cardiovascular outcomes'.


## File content 


* Figure2_annotations.tsv.gz

    Contains cell annotations used in figure 2. The annotations are either '.' 

    when the p-value is larger than 0.05, or the point estimate

    (log odds ratio, or mean difference).

* Figure2_pvalues.tsv.gz

    Contains the -log10(p-values) used to colour the cells in figure 2. 

* Figure3_edges.tsv.gz

    Lists the network connections between the `Source` (the exposure) and

    the `Target` (the outcome), as well as the effect direction. 

* Figure3_nodes.tsv.gz

    Lists the node text for the network presented in Figure 3.

* Figure4_tables.xlsx

    Lists the point estimates with standard error and confidence intervals

    for the forest plot presented in Figure 4. Includes a prioritization 

    column.

* Figure5_tables.xlsx

    Lists the point estimates with standard error and confidence intervals

    for the forest plot presented in Figure 5. Includes a prioritization 

    column.

* Figure6_exposure_panel.tsv.gz

    Contains the -log10(p-values) of the Kolmogorov-Smirnov tests.

* Figure6_outcome_panel.tsv.gz

    Contains the -log10(p-values) of the Kolmogorov-Smirnov tests.


Funding

PG/18/5033837

PG/22/10989

Accelerator Award (round 1)

British Heart Foundation

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