posted on 2020-03-26, 16:40authored byZiad Hussein, Nigel Glynn, Niamh Martin, Akram Alkrekshi, Nigel Mendoza, Ramesh Nair, Katherine McCullough, Hani J. Marcus, Neil DorwardNeil Dorward, Joan Grieve, Naomi Fersht, Pierre-Marc BoulouxPierre-Marc Bouloux, Maralyn Druce, Stephanie Baldeweg
Craniopharyngiomas are neoplasms of the sellar and parasellar region
which develop from the epithelium of the primordial craniopharyngeal canal
(Rathke's pouch). Despite their WHO classification as type 1 tumours,
craniopharyngiomas are associated with multiple comorbidities including
hypopituitarism, obesity and somnolence
In this clinical study, we investigated
the management and outcomes of a large cohort of patients with
craniopharyngioma, both childhood and adult-onset, from three tertiary
endocrine centres in the United Kingdom. The primary aim of this study
was to examine temporal trends in the management of craniopharyngioma and their
impact on long-term patient’s endocrine function.