Extracellular spinal recordings: dorsal and ventral root conduction velocities
dataset
posted on 2023-03-27, 14:22 authored by Amanda PocratskyAmanda Pocratsky, Filipe Do Nascimento Xavier FernandesFilipe Do Nascimento Xavier Fernandes, Gorkem OzyurtGorkem Ozyurt, Ian WhiteIan White, Roisin Sullivan, Benjamin O'CallaghanBenjamin O'Callaghan, Calvin Smith, Sunaina SuranaSunaina Surana, Marco BeatoMarco Beato, Rob BrownstoneRob Brownstone<p><strong>Afferent (dorsal root) and efferent (ventral root) conduction velocity datasets associated with </strong><em><strong>Pocratsky et al 2023, Science Translational Medicine</strong></em></p>
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<p>Data generated from isolated spinal cord preparations with dorsal and ventral roots attached. Groups: littermate control (Cdx2::wt;Tor1a-wt/frt) and spinal Tor1a d-cko (Cdx2::FlpO;Tor1a-frt/frt) mice that develop early onset generalised torsional dystonia.</p>
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<p><strong>Conduction_velocity.xlsx </strong>- datafile: dorsal and ventral root conduction velocities (whole root stimulation at 2x threshold)</p>
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<p><strong>Conduction_time.xlsx</strong> - datafile: scaled conduction times for dorsal and ventral roots. </p>
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<p>Full methodological detail can be found in publication</p>
Funding
The contribution of spinal circuit dysfunction to movement disorganisation in dystonia
Beyond The Basal Ganglia: Spinal Circuit Dysfunction As A Final Pathway For Movement Disorganisation In Tor1a Dystonia
Medical Research Council
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