University College London
Browse
1/1
4 files

Extracellular spinal recordings: monosynaptic reflexes

In vitro monosynaptic reflex dataset associated with Pocratsky et al 2023, Science Translational Medicine


Data generated from isolated lumbar spinal cord preparations with stimuli applied to dorsal roots and monosynaptic reflexes recorded from homonymouse ventral roots. Groups: littermate control (Cdx2::wt;Tor1a-wt/frt) and spinal Tor1a d-cko mice (Cdx2::FlpO;Tor1a-frt/frt) that develop early onset generalised torsional dystonia.


monosynapticReflex_latency2onset.xlsx - datafile: latency to onset of the evoked response


monosynapticReflex_responseDur.xlsx - datafile: duration of the evoked response


monosynapticReflex_maxAmp.xlsx - datafile: maximum absolute peak amplitude evoked at maximal stimulation


MSR_script.sgs  - script: CED Signal script file to measure and format in vitro monosynaptic reflexes


Full methodological detail can be found in manuscript

Funding

Tuning spinal motoneurons for movement.

Wellcome Trust

Find out more...

The contribution of spinal circuit dysfunction to movement disorganisation in dystonia

Beyond The Basal Ganglia: Spinal Circuit Dysfunction As A Final Pathway For Movement Disorganisation In Tor1a Dystonia

Medical Research Council

Find out more...

History

Usage metrics

    University College London

    Licence

    Exports

    RefWorks
    BibTeX
    Ref. manager
    Endnote
    DataCite
    NLM
    DC