Huntingtin Degradome Foundation Atlas

<h2><b>Huntingtin Degradome Foundation Atlas</b></h2><p dir="ltr">This open-access dataset introduces Version 1 of the Huntingtin Degradome Foundation Atlas, a curated proteolytic peptide resource designed to accelerate translational research in neurodegeneration.</p><p dir="ltr">The atlas integrates proteolytic fragments from Huntingtin wild-type (WT), Q75, and Q103 isoforms, capturing the impact of polyglutamine repeat expansions that drive Huntington disease (HD) pathology. By mapping and annotating these breakdown products, the dataset provides a framework for tracking disease-relevant proteolysis.</p><p dir="ltr">These data are particularly relevant for clinical researchers engaged in antisense oligonucleotide (ASO) trials or biomarker-guided therapeutic development. The atlas allows cross-referencing of peptide signatures with treatment response, supporting biomarker discovery, stratification, and outcome validation in HD studies.</p><p dir="ltr">Each peptide entry is annotated with detailed chemical features of its proteolytic origin. The dataset is delivered as a comma-delimited ASCII (.csv) file for integration into bioinformatics and statistical pipelines. For efficient distribution, it is provided in compressed format, which can be extracted using:</p><h4>tar -xvJf Huntingtin_WT_Degradome_Foundation_Atlas_v1.tar.gz<br></h4><p dir="ltr"><b>Reproducibility</b><br>All datasets can be regenerated using open-source tools (Python, BLAST, SAS). Fully documented Python scripts are included in the repository to ensure transparency and adaptability to local environments, following the methodology described in [1].</p><p dir="ltr"><br></p><p dir="ltr"><b>Reference</b><br>[1] Petzold A. <i>Proteolysis-Based Biomarker Repertoire of the Neurofilament Proteome.</i> J Neurochem. 2025 Mar;169(3):e70023. doi: 10.1111/jnc.70023. PMID: 40066701; PMCID: PMC11894590.</p><p><br></p>