Intracellular spinal recordings: patch-clamp and dorsal root evoked excitatory post-synaptic currents

<p><strong>Intracellular recording dataset from spinal motoneurons associated with </strong><em><strong>Pocratsky et al 2023, Science Translational Medicine</strong></em></p> <p><br></p> <p>Data generated from isolated postnatal spinal cord preparations with dorsal roots attached (postnatal day 1-13). Groups: littermate controls (Cdx2::wt;Tor1a-wt/frt) and spinal <em>Tor1a</em> d-cko mice (Cdx2::FlpO;Tor1a-frt/frt) that develop early onset generalised torsional dystonia. </p> <p><br></p> <p><strong>Intracellular_recordings.xlsx</strong> - dataset: intrinsic lumbar spinal motoneuron properties and dorsal root-evoked excitatory post-synaptic currents (EPSCs)</p> <p><br></p> <p><strong>210616_DIC_lumbarMNs_P9-control.nd2</strong>: differential interference contract (DIC) image of lumbar motoneuron pool in control mouse</p> <p><br></p> <p><strong>210616_DIC_lumbarMNs_P9-spinalTor1aCKO.nd2</strong>: DIC image of lumbar motoneuron pool in spinal <em>Tor1a </em>d-cko mouse</p> <p><br></p> <p>Full methodological detail can be found in manuscript</p> <p><br></p>