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Intracellular spinal recordings: patch-clamp and dorsal root evoked excitatory post-synaptic currents

Intracellular recording dataset from spinal motoneurons associated with Pocratsky et al 2023, Science Translational Medicine

Data generated from isolated postnatal spinal cord preparations with dorsal roots attached (postnatal day 1-13). Groups: littermate controls (Cdx2::wt;Tor1a-wt/frt) and spinal Tor1a d-cko mice (Cdx2::FlpO;Tor1a-frt/frt) that develop early onset generalised torsional dystonia. 

Intracellular_recordings.xlsx - dataset: intrinsic lumbar spinal motoneuron properties and dorsal root-evoked excitatory post-synaptic currents (EPSCs)

210616_DIC_lumbarMNs_P9-control.nd2: differential interference contract (DIC) image of lumbar motoneuron pool in control mouse

210616_DIC_lumbarMNs_P9-spinalTor1aCKO.nd2: DIC image of lumbar motoneuron pool in spinal Tor1a d-cko mouse

Full methodological detail can be found in manuscript


Tuning spinal motoneurons for movement.

Wellcome Trust

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The contribution of spinal circuit dysfunction to movement disorganisation in dystonia

Beyond The Basal Ganglia: Spinal Circuit Dysfunction As A Final Pathway For Movement Disorganisation In Tor1a Dystonia

Medical Research Council

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