Makris et al. - scRNAseq data - Podoplanin deletion in lymph node fibroblastic stroma
dataset
posted on 2024-12-18, 10:33 authored by Sophie ActonSophie Acton, Spiros MakrisSpiros Makris<p dir="ltr">These data provide single cell transcriptomic sequences for fibroblastic stromal cells (CD45-CD31-) and immune cells (CD45+CD31+) isolated from murine skin-draining lymph nodes. We have compared Wild type C57BL/6J mice with a genetically modified <i>Pdgfra</i><sup>mGFP-CreERT2 </sup>x <i>Pdpn</i><sup>flox/flox</sup> to induce deletion of the gene encoding Podoplanin conditionally from fibroblasts.</p><p dir="ltr">These data support the publication - https://doi.org/10.1101/2022.12.01.518753</p><p dir="ltr"><br></p><p dir="ltr"><b>Files included:</b></p><p dir="ltr">Raw data h5 files, 10X Genomics transcriptional sequencing</p><p dir="ltr"><br></p><p dir="ltr">Control_CD45-CD31-,</p><p dir="ltr">PDPNdel_CD45-CD31-,</p><p dir="ltr">Control_CD45+CD31+</p><p dir="ltr">PDPNdel_CD45+CD31+</p>
Funding
Cancer Research UK Careers Development Fellowship CRUK-A19763
Rosetrees Trust Foundation PGS22 100023-CD1
Cancer Research UK Senior Fellowship CRUK - RCCSCF-May22\100001
History
Related Materials
- 1. arXiv - Is supplement to Lymph Node Fibroblast Phenotypes and Immune Crosstalk Regulated by Podoplanin Activity
