scRNA and scTCR data for the manuscript 'Determinants of anti-PD-1 response and resistance in clear cell renal cell carcinoma'
Samples: Tumour infiltrating lymphocyes taken from two ccRCC patients post anti-PD-1 (nivolumab) treatment. One responder patient, one non-responder patient. For each patient cells were split by IgG4 binding (IgG4 = proxy for nivolumab binding), followed by 10x paired scRNA and scTCR sequencing.
Data analysis: sequencing files were demultiplexed and mapped to the hg38 genome and VDJ reference using cellranger count and cellranger vdj respectively. Expression matrices and VDJ annotations are provided in this submission. Also provided is cell metadata containing UMAP co-ordinates and other information pertinent to this study.