University College London
Revised version_Supplementary Tables_NGS_JHEP 190523.xlsx (2.73 MB)

Primary human Hepatic Stellate Cells and PNPLA3 I148M

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posted on 2023-11-19, 00:10 authored by Krista RomboutsKrista Rombouts, Elisabetta Caon

 A) RNA sequencing was performed on 2D-cultured primary human Hepatic Stellate Cells (HSC) genotyped for the PNPLA3 I148M variant. 

B) RNA sequencing from liver biopsies of genotyped PNPLA3 patients, previously published (http:// dx. doi. org/ 10. 1136/gutjnl- 2019- 319226).

C) Comparison of both datasets of A and B.

D) Cell behaviour was evaluated in HSCs wild type (WT) or carrying I148M PNPLA3 cultured on 3D extracellular matrix (ECM) scaffolds from human healthy and cirrhotic liver with/without TGFB1 and NanoString was employed.  

All datasets are available in Excel files.