Validation of mouse model: qPCR and Western blots probing for Tor1a-torsinA
Model validation dataset associated with Pocratsky et al 2023, Science Translational Medicine
Data generated from postnatal day 18 littermate control (Cdx2::wt;Tor1a-wt/frt) and spinal Tor1a d-cko mice (Cdx2::FlpO;Tor1a-frt/frt) that develop early onset generalised torsional dystonia. Whole tissues were snap frozen and processed for expression of Tor1a and torsinA protein. Raw images of Western blots provided
Validation_qPCR.xlsx - dataset: Tor1a expression in brains and lumbar spinal cords
Validation_Westerns.xlsx - dataset: torsinA expression in brains and lumbar spinal cords
Western_metadata: details for attached images of blots
Full methodological detail provided in manuscript
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