When drug treatments bias genetic studies: data files
datasetposted on 2019-08-08, 07:20 authored by Floriaan SchmidtFloriaan Schmidt, Hiddo J. Lambers Heerspink, Petra Denig, Chris FinanChris Finan, Rolf H.H. Groenwold
Numerical data underlying the figures of PLOS ONE paper: "When drug treatments bias genetic studies: mediation and interaction".
The files "Data_Figure3-4" pertain to simulation results described in the paper and appendix.
The file "Data_Figure5" contains aggregated level data on the proportion and type of diabetes medication prescribed over a 3 year period. Data were obtained from a Dutch diabetes cohort 'GAINTT': https://www.giantt.nl/nl/
The file "Data_Figure6" contains mean difference and p-values of 100+ genetic variants and their association with longitudinal (over a 3 year period) HbA1c levels. Results are stratified for treatment modelling strategy.
These data have been shared inline with the journal's open access policy.