Postnatal video recordings: spinal Tor1a d-cko mice develop early onset generalised torsional dystonia

<p><strong>Supplemental movies of the dystonic-like phenotype in spinal </strong><em><strong>Tor1a </strong></em><strong>d-cko mice associated with </strong><em><strong>Pocratsky et al 2023, Science Translational Medicine</strong></em></p> <p><br></p> <p>Videos were generated throughout postnatal development from litterate controls (Cdx2::wt;Tor1a-wt/frt) and spinal Tor1a d-cko mice (Cdx2::FlpO;Tor1a-frt/frt) that develop early onset generalised torsional dystonia. </p> <p><br></p> <p><strong>Pocratsky2023_MovieS1:</strong> Representative postnatal video recordings of littermate control (#1161022) vs spinal <em>Tor1a</em> d-cko (#1161023) showing onset and progression of dystonic-like signs over postnatal maturation.  </p> <p><br></p> <p><strong>Pocratsky2023_MovieS2:</strong> Tail suspension-induced paw clasping and clenching in spinal <em>Tor1a</em> d-cko mice. </p> <p><br></p> <p><strong>Pocratsky2023_MovieS3:</strong> Range of discoordinated limb movements observed in pre-weaned spinal <em>Tor1a</em> d-cko mice.</p> <p><br></p> <p><strong>Pocratsky2023_MovieS4:</strong> Range of trunk torsion and instability observed throughout postnatal maturation in spinal <em>Tor1a</em> d-cko mice.</p> <p><br></p> <p><strong>Pocratsky2023_MovieS5:</strong> Range of abnormal postures observed at rest and during voluntary movements in spinal <em>Tor1a</em> d-cko mice.</p> <p><br></p> <p><strong>Pocratsky2023_MovieS6:</strong> Intrusion of tremulous-like phenotype in spinal <em>Tor1a</em> d-cko mice. </p> <p><br></p> <p><strong>Pocratsky2023_MovieS7:</strong> Longitudinal postnatal video recordings from littermate control (Avil-wt/wt;Tor1a-wt/flox) and dorsal root ganglia (DRG)-specific <em>Tor1a </em>d-cko (Avil-wt/cre;Tor1a-flox/flox)</p> <p><br></p> <p>Full methodological detail can be found in manuscript.</p> <p><br></p>