University College London
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Postnatal video recordings: spinal Tor1a d-cko mice develop early onset generalised torsional dystonia

Supplemental movies of the dystonic-like phenotype in spinal Tor1a d-cko mice associated with Pocratsky et al 2023, Science Translational Medicine

Videos were generated throughout postnatal development from litterate controls (Cdx2::wt;Tor1a-wt/frt) and spinal Tor1a d-cko mice (Cdx2::FlpO;Tor1a-frt/frt) that develop early onset generalised torsional dystonia. 

Pocratsky2023_MovieS1: Representative postnatal video recordings of littermate control (#1161022) vs spinal Tor1a d-cko (#1161023) showing onset and progression of dystonic-like signs over postnatal maturation.  

Pocratsky2023_MovieS2: Tail suspension-induced paw clasping and clenching in spinal Tor1a d-cko mice. 

Pocratsky2023_MovieS3: Range of discoordinated limb movements observed in pre-weaned spinal Tor1a d-cko mice.

Pocratsky2023_MovieS4: Range of trunk torsion and instability observed throughout postnatal maturation in spinal Tor1a d-cko mice.

Pocratsky2023_MovieS5: Range of abnormal postures observed at rest and during voluntary movements in spinal Tor1a d-cko mice.

Pocratsky2023_MovieS6: Intrusion of tremulous-like phenotype in spinal Tor1a d-cko mice. 

Pocratsky2023_MovieS7: Longitudinal postnatal video recordings from littermate control (Avil-wt/wt;Tor1a-wt/flox) and dorsal root ganglia (DRG)-specific Tor1a d-cko (Avil-wt/cre;Tor1a-flox/flox)

Full methodological detail can be found in manuscript.


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Wellcome Trust

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The contributions of spinal circuit dysfunction to movement disorganisation in dystonia

Beyond The Basal Ganglia: Spinal Circuit Dysfunction As A Final Pathway For Movement Disorganisation In Tor1a Dystonia

Medical Research Council

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