Dimitrios Evangelopoulos

Lecturer in Microbiology (Health sciences)


  • Bioactive Pyridine-N-oxide Disulfides from Allium stipitatum
  • Improving the Tuberculosis Drug Development Pipeline
  • Tetrahydroisoquinolines affect the whole-cell phenotype of Mycobacterium tuberculosis by inhibiting the ATP-dependent MurE ligase
  • Understanding anti-tuberculosis drug efficacy: Rethinking bacterial populations and how we model them
  • Characterisation of a putative AraC transcriptional regulator from Mycobacterium smegmatis
  • Profiling persistent tubercule bacilli from patient sputa during therapy predicts early drug efficacy
  • Repurposing drugs for treatment of tuberculosis: A role for non-steroidal anti-inflammatory drugs
  • Design and Synthesis of 1-((1,5-Bis(4-chlorophenyl)-2-methyl-1H-pyrrol-3-yl)methyl)-4-methylpiperazine (BM212) and N-Adamantan-2-yl-N′-((E)-3,7-dimethylocta-2,6-dienyl)ethane-1,2-diamine (SQ109) Pyrrole Hybrid Derivatives: Discovery of Potent Antitubercular Agents Effective against Multidrug-Resistant Mycobacteria
  • Effective anti-tuberculosis therapy correlates with plasma small RNA
  • Antagonistic effects of indoloquinazoline alkaloids on antimycobacterial activity of evocarpine
  • DNA sequence-selective C8-linked pyrrolobenzodiazepine-heterocyclic polyamide conjugates show anti-tubercular-specific activities
  • Antitubercular activity of Arctium lappa and Tussilago farfara extracts and constituents
  • Optimising molecular diagnostic capacity for effective control of tuberculosis in high-burden settings
  • Investigation of the mycobacterial enzyme HsaD as a potential novel target for anti-tubercular agents using a fragment-based drug design approach
  • ProTides of N-(3-(5-(2′-deoxyuridine))prop-2-ynyl)octanamide as potential anti-tubercular and anti-viral agents
  • Assessment of treatment response by colony forming units, time to culture positivity and the molecular bacterial load assay compared in a mouse tuberculosis model
  • Analogues of Disulfides from Allium stipitatum Demonstrate Potent Anti-tubercular Activities through Drug Efflux Pump and Biofilm Inhibition
  • Rapid Methods for Testing Inhibitors of Mycobacterial Growth
  • Synthesis and Biological Evaluation of Purpurealidin E-Derived Marine Sponge Metabolites: Aplysamine-2, Aplyzanzine A, and Suberedamines A and B
  • The Properties of Solutions of Isoniazid in Water and Dimethylsulfoxide
  • Versatile Routes to Marine Sponge Metabolites through Benzylidene Rhodanines
  • An antibacterial from Hypericum acmosepalum inhibits ATP-dependent MurE ligase from Mycobacterium tuberculosis
  • Antitubercular specific activity of ibuprofen and the other 2-arylpropanoic acids using the HT-SPOTi whole-cell phenotypic assay
  • 2-Hydroxy-substituted cinnamic acids and acetanilides are selective growth inhibitors of Mycobacterium tuberculosis
  • Characterisation of ATP-Dependent Mur Ligases Involved in the Biogenesis of Cell Wall Peptidoglycan in Mycobacterium tuberculosis
  • Antimycobacterials from Lovage root (Ligusticum officinale Koch)
  • Anti-tubercular screening of natural products from Colombian plants: 3-methoxynordomesticine, an inhibitor of MurE ligase of Mycobacterium tuberculosis
  • Characterization of an oxidoreductase from the arylamine N-acetyltransferase operon in Mycobacterium smegmatis
  • A new plant-derived antibacterial is an inhibitor of efflux pumps in Staphylococcus aureus
  • Interaction of N-methyl-2-alkenyl-4-quinolones with ATP-dependent MurE ligase of Mycobacterium tuberculosis: Antibacterial activity, molecular docking and inhibition kinetics
  • Streptococcal dTDP‐L‐rhamnose biosynthesis enzymes: functional characterization and lead compound identification
  • A novel regulatory factor affecting the transcription of methionine biosynthesis genes in Escherichia coli experiencing sustained nitrogen starvation
  • Pediatric tuberculosis-human immunodeficiency virus co-infection in the United Kingdom highlights the need for better therapy monitoring tools: a case report
  • Comparative fitness analysis of D-cycloserine resistant mutants reveals both fitness-neutral and high-fitness cost genotypes
  • New InhA Inhibitors Based on Expanded Triclosan and Di-Triclosan Analogues to Develop a New Treatment for Tuberculosis
  • Arylamine N-acetyltransferase in mycobacteria
  • Clinical outcomes of COVID-19 in long-term care facilities for people with epilepsy
  • Pandemic peak SARS-CoV-2 infection and seroconversion rates in London frontline health-care workers
  • Carprofen elicits pleiotropic mechanisms of bactericidal action with the potential to reverse antimicrobial drug resistance in tuberculosis
  • A role for a conserved kinase in the transcriptional control of methionine biosynthesis in Escherichia coli experiencing sustained nitrogen starvation
  • Posterior stabilization of cervical spine injuries using the Roy-Camille plates: A long-term follow-up
  • Improving diagnosis and monitoring of treatment response in pulmonary tuberculosis using the molecular bacterial load assay (MBLA)
  • Author Correction: Scalable and robust SARS-CoV-2 testing in an academic center (Nature Biotechnology, (2020), 38, 8, (927-931), 10.1038/s41587-020-0588-y)
  • Scalable and robust SARS-CoV-2 testing in an academic center
  • Targeting mononuclear phagocytes for eradicating intracellular parasites
  • Estimating the effectiveness of routine asymptomatic PCR testing at different frequencies for the detection of SARS-CoV-2 infections
  • Polymersomes Eradicating Intracellular Bacteria
  • Tuberculosis bacillary load, an early marker of disease severity: The utility of tuberculosis Molecular Bacterial Load Assay
  • Antibiotic resistance evasion is explained by rare mutation frequency and not by lack of compensatory mechanisms
  • A new strategy for hit generation: Novel in cellulo active inhibitors of CYP121A1 from Mycobacterium tuberculosis via a combined X-ray crystallographic and phenotypic screening approach (XP screen)
  • Arylamine N-acetyltransferases in mycobacteria
  • Temperature stability of proteins essential for the intracellular survival of Mycobacterium tuberculosis
  • Culture-Free Enumeration of Mycobacterium tuberculosis in Mouse Tissues Using the Molecular Bacterial Load Assay for Preclinical Drug Development
  • Pre-Clinical Tools for Predicting Drug Efficacy in Treatment of Tuberculosis

Usage metrics

Co-workers & collaborators

Timothy McHugh

Timothy McHugh

Dimitrios Evangelopoulos's public data