Dimitrios Evangelopoulos

Publications

• Bioactive Pyridine-N-oxide Disulfides from Allium stipitatum
• Improving the Tuberculosis Drug Development Pipeline
• Tetrahydroisoquinolines affect the whole-cell phenotype of Mycobacterium tuberculosis by inhibiting the ATP-dependent MurE ligase
• Understanding anti-tuberculosis drug efficacy: Rethinking bacterial populations and how we model them
• Characterisation of a putative AraC transcriptional regulator from Mycobacterium smegmatis
• Profiling persistent tubercule bacilli from patient sputa during therapy predicts early drug efficacy
• Repurposing drugs for treatment of tuberculosis: A role for non-steroidal anti-inflammatory drugs
• Design and Synthesis of 1-((1,5-Bis(4-chlorophenyl)-2-methyl-1H-pyrrol-3-yl)methyl)-4-methylpiperazine (BM212) and N-Adamantan-2-yl-N′-((E)-3,7-dimethylocta-2,6-dienyl)ethane-1,2-diamine (SQ109) Pyrrole Hybrid Derivatives: Discovery of Potent Antitubercular Agents Effective against Multidrug-Resistant Mycobacteria
• Effective anti-tuberculosis therapy correlates with plasma small RNA
• Antagonistic effects of indoloquinazoline alkaloids on antimycobacterial activity of evocarpine
• DNA sequence-selective C8-linked pyrrolobenzodiazepine-heterocyclic polyamide conjugates show anti-tubercular-specific activities
• Antitubercular activity of Arctium lappa and Tussilago farfara extracts and constituents
• Optimising molecular diagnostic capacity for effective control of tuberculosis in high-burden settings
• Investigation of the mycobacterial enzyme HsaD as a potential novel target for anti-tubercular agents using a fragment-based drug design approach
• ProTides of N-(3-(5-(2′-deoxyuridine))prop-2-ynyl)octanamide as potential anti-tubercular and anti-viral agents
• Assessment of treatment response by colony forming units, time to culture positivity and the molecular bacterial load assay compared in a mouse tuberculosis model
• Analogues of Disulfides from Allium stipitatum Demonstrate Potent Anti-tubercular Activities through Drug Efflux Pump and Biofilm Inhibition
• Rapid Methods for Testing Inhibitors of Mycobacterial Growth
• Synthesis and Biological Evaluation of Purpurealidin E-Derived Marine Sponge Metabolites: Aplysamine-2, Aplyzanzine A, and Suberedamines A and B
• The Properties of Solutions of Isoniazid in Water and Dimethylsulfoxide
• Versatile Routes to Marine Sponge Metabolites through Benzylidene Rhodanines
• An antibacterial from Hypericum acmosepalum inhibits ATP-dependent MurE ligase from Mycobacterium tuberculosis
• Antitubercular specific activity of ibuprofen and the other 2-arylpropanoic acids using the HT-SPOTi whole-cell phenotypic assay
• 2-Hydroxy-substituted cinnamic acids and acetanilides are selective growth inhibitors of Mycobacterium tuberculosis
• Characterisation of ATP-Dependent Mur Ligases Involved in the Biogenesis of Cell Wall Peptidoglycan in Mycobacterium tuberculosis
• Antimycobacterials from Lovage root (Ligusticum officinale Koch)
• Anti-tubercular screening of natural products from Colombian plants: 3-methoxynordomesticine, an inhibitor of MurE ligase of Mycobacterium tuberculosis
• Characterization of an oxidoreductase from the arylamine N-acetyltransferase operon in Mycobacterium smegmatis
• A new plant-derived antibacterial is an inhibitor of efflux pumps in Staphylococcus aureus
• Interaction of N-methyl-2-alkenyl-4-quinolones with ATP-dependent MurE ligase of Mycobacterium tuberculosis: Antibacterial activity, molecular docking and inhibition kinetics
• Streptococcal dTDP‐L‐rhamnose biosynthesis enzymes: functional characterization and lead compound identification
• A novel regulatory factor affecting the transcription of methionine biosynthesis genes in Escherichia coli experiencing sustained nitrogen starvation
• Pediatric tuberculosis-human immunodeficiency virus co-infection in the United Kingdom highlights the need for better therapy monitoring tools: a case report
• Comparative fitness analysis of D-cycloserine resistant mutants reveals both fitness-neutral and high-fitness cost genotypes
• New InhA Inhibitors Based on Expanded Triclosan and Di-Triclosan Analogues to Develop a New Treatment for Tuberculosis
• Arylamine N-acetyltransferase in mycobacteria
• Clinical outcomes of COVID-19 in long-term care facilities for people with epilepsy
• Pandemic peak SARS-CoV-2 infection and seroconversion rates in London frontline health-care workers
• Carprofen elicits pleiotropic mechanisms of bactericidal action with the potential to reverse antimicrobial drug resistance in tuberculosis
• A role for a conserved kinase in the transcriptional control of methionine biosynthesis in Escherichia coli experiencing sustained nitrogen starvation
• Posterior stabilization of cervical spine injuries using the Roy-Camille plates: A long-term follow-up
• Improving diagnosis and monitoring of treatment response in pulmonary tuberculosis using the molecular bacterial load assay (MBLA)
• Author Correction: Scalable and robust SARS-CoV-2 testing in an academic center (Nature Biotechnology, (2020), 38, 8, (927-931), 10.1038/s41587-020-0588-y)
• Scalable and robust SARS-CoV-2 testing in an academic center
• Targeting mononuclear phagocytes for eradicating intracellular parasites
• Estimating the effectiveness of routine asymptomatic PCR testing at different frequencies for the detection of SARS-CoV-2 infections
• Polymersomes Eradicating Intracellular Bacteria
• Tuberculosis bacillary load, an early marker of disease severity: The utility of tuberculosis Molecular Bacterial Load Assay
• Antibiotic resistance evasion is explained by rare mutation frequency and not by lack of compensatory mechanisms
• A new strategy for hit generation: Novel in cellulo active inhibitors of CYP121A1 from Mycobacterium tuberculosis via a combined X-ray crystallographic and phenotypic screening approach (XP screen)
• Arylamine N-acetyltransferases in mycobacteria
• Temperature stability of proteins essential for the intracellular survival of Mycobacterium tuberculosis
• Culture-Free Enumeration of Mycobacterium tuberculosis in Mouse Tissues Using the Molecular Bacterial Load Assay for Preclinical Drug Development
• Pre-Clinical Tools for Predicting Drug Efficacy in Treatment of Tuberculosis