Jack Wells

Publications

• CO2 signaling mediates neurovascular coupling in the cerebral cortex
• Non-Invasive MRI of Blood-Cerebrospinal Fluid Barrier Function.
• Volumetric Spatial Correlations of Neurovascular Coupling Studied using Single Pulse Opto-fMRI.
• Application of neurite orientation dispersion and density imaging (NODDI) to a tau pathology model of Alzheimer's disease
• Reduction of errors in ASL cerebral perfusion and arterial transit time maps using image de-noising
• Measuring biexponential transverse relaxation of the ASL signal at 9.4 T to estimate arterial oxygen saturation and the time of exchange of labeled blood water into cortical brain tissue
• In amnio mri of mouse embryos
• A critical role for purinergic signalling in the mechanisms underlying generation of BOLD fMRI responses
• Amniotic fluid stem cells prevent development of ascites in a neonatal rat model of necrotizing enterocolitis
• Cerebral blood flow changes during pilocarpine-induced status epilepticus activity in the rat hippocampus
• In vivo imaging of tau pathology using multi-parametric quantitative MRI
• Targeted magnetic delivery and tracking of cells using a magnetic resonance imaging system
• Pharmacological MRI with Simultaneous Measurement of Cerebral Perfusion and Blood-Cerebrospinal Fluid Barrier Function using Interleaved Echo-Time Arterial Spin Labelling
• Electrochemical carbon fiber-based technique for simultaneous recordings of brain tissue PO2, pH, and extracellular field potentials.
• A critical role for the ATP-sensitive potassium channel subunit KIR6.1 in the control of cerebral blood flow.
• Tissue magnetic susceptibility mapping as a marker of tau pathology in Alzheimer's disease.
• Comparison of In Vivo and Ex Vivo MRI for the Detection of Structural Abnormalities in a Mouse Model of Tauopathy.
• Acute changes in liver tumour perfusion measured non-invasively with arterial spin labelling.
• Hepatic arterial spin labelling MRI: an initial evaluation in mice.
• Imaging the paediatric lung: what does nanotechnology have to offer?
• Automatic structural parcellation of mouse brain MRI using multi-atlas label fusion.
• Monitoring ferumoxide-labelled neural progenitor cells and lesion evolution by magnetic resonance imaging in a model of cell transplantation in cerebral ischaemia.
• Influence of different isoflurane anesthesia protocols on murine cerebral hemodynamics measured with pseudo‐continuous arterial spin labeling
• MR angiography and arterial spin labelling
• Is your system calibrated? MRI gradient system calibration for pre-clinical, high-resolution imaging
• Enhanced tissue differentiation in the developing mouse brain using magnetic resonance micro-histology
• In vivo Hadamard encoded Continuous arterial spin labeling (H-CASL)
• Diffusion microscopic MRI of the mouse embryo: Protocol and practical implementation in the splotch mouse model
• Evaluation of skeletal tissue repair, Part 2: Enhancement of skeletal tissue repair through dual-growth-factor-releasing hydrogels within an ex vivo chick femur defect model
• Amniotic fluid stem cells improve survival and enhance repair of damaged intestine in necrotising enterocolitis via a COX-2 dependent mechanism
• Cardiac arterial spin labeling using segmented ECG-gated Look-Locker FAIR: Variability and repeatability in preclinical studies
• The importance of RF bandwidth for effective tagging in pulsed arterial spin labeling MRI at 9.4T
• Increased cerebral vascular reactivity in the tau expressing rTg4510 mouse: Evidence against the role of tau pathology to impair vascular health in Alzheimer's disease
• Imaging seizure-induced inflammation using an antibody targeted iron oxide contrast agent
• Imaging the accumulation and suppression of tau pathology using multiparametric MRI
• FMRI response to blue light delivery in the naïve brain: Implications for combined optogenetic fMRI studies
• Evaluation of skeletal tissue repair, Part 1: Assessment of novel growth-factor-releasing hydrogels in an ex vivo chick femur defect model
• Non-invasive imaging of CSF-mediated brain clearance pathways via assessment of perivascular fluid movement with diffusion tensor MRI
• CO2 signalling mediates neurovascular coupling in the cerebral cortex
• Increased blood-brain barrier permeability to water in the aging brain detected using noninvasive multi-TE ASL MRI.
• Impaired glymphatic function and clearance of tau in an Alzheimer's disease model.
• Non-invasive MRI of brain clearance pathways using multiple echo time arterial spin labelling: an aquaporin-4 study.
• fMRI mapping of the visual system in the mouse brain with interleaved snapshot GE-EPI.
• MRI of cerebral micro-vascular flow patterns: A multi-direction diffusion-weighted ASL approach.
• Functional MRI of the Reserpine-Induced Putative Rat Model of Fibromyalgia Reveals Discriminatory Patterns of Functional Augmentation to Acute Nociceptive Stimuli.
• Astrocytes monitor cerebral perfusion and control systemic circulation to maintain brain blood flow.
• Non-invasive MRI of Blood-Cerebrospinal Fluid-Barrier Function: a Functional Biomarker of Early Alzheimer’s Disease Pathology
• Influence of the Glymphatic System on α-Synuclein Propagation: Role of Aquaporin-4 and the Dystrophin-Associated Protein Complex
• Inhibiting Ca2+ channels in Alzheimer’s disease model mice relaxes pericytes, improves cerebral blood flow and reduces immune cell stalling and hypoxia
• Evidence for reduced choroid plexus volume in the aged brain
• Characterizing the origin of the arterial spin labelling signal in MRI using a multiecho acquisition approach