Thomas Burgoyne

Publications

• New light on photoreceptor renewal.
• PCD Detect: enhancing ciliary features through image averaging and classification
• Physiological and Pathophysiological Aspects of Primary Cilia—A Literature Review with View on Functional and Structural Relationships in Cartilage
• A Comparison Between Chlamydomonas Flagella And Human Cilia By Electron Tomography
• WASH and Tsg101/ALIX-dependent diversion of stress-internalized EGFR from the canonical endocytic pathway
• The relationship between ER–multivesicular body membrane contacts and the ESCRT machinery
• The Study Of Primary Ciliary Dyskinesia In Difficult Cases Using Electron Tomography
• Retinal Pigment Epithelial Cells Mitigate the Effects of Complement Attack by Endocytosis of C5b-9.
• Three-Dimensional Structure of Vertebrate Muscle Z-Band: The Small-Square Lattice Z-Band in Rat Cardiac Muscle
• Methamphetamine-induced nitric oxide promotes vesicular transport in blood–brain barrier endothelial cells
• Differential Apicobasal VEGF Signaling at Vascular Blood-Neural Barriers
• Generation of a Three-Dimensional Ultrastructural Model of Human Respiratory Cilia
• Rod disc renewal occurs by evagination of the ciliary plasma membrane that makes cadherin-based contacts with the inner segment
• Phenotypic variability of CCDC103 mutation in British Pakistani children with Primary Ciliary Dyskinesia (PCD).
• Gene discovery for motile cilia disorders: mutation spectrum in primary ciliary dyskinesia and discovery of mutations in CCDC151.
• Regulation of melanosome number, shape and movement in the zebrafish retinal pigment epithelium by OA1 and PMEL.
• Calcium signaling at ER membrane contact sites.
• CCDC151 mutations cause primary ciliary dyskinesia by disruption of the outer dynein arm docking complex formation.
• Characterizing the ultrastructure of primary ciliary dyskinesia transposition defect using electron tomography.
• Targeted NGS gene panel identifies mutations in RSPH1 causing primary ciliary dyskinesia and a common mechanism for ciliary central pair agenesis due to radial spoke defects.
• Expression of OA1 limits the fusion of a subset of MVBs with lysosomes - a mechanism potentially involved in the initial biogenesis of melanosomes.
• Three dimensional ultrastructure of human respiratory cilia in health and disease.
• Recessive HYDIN mutations cause primary ciliary dyskinesia without randomization of left-right body asymmetry.
• Mutations in REEP6 Cause Autosomal-Recessive Retinitis Pigmentosa.
• Symmetric arrangement of mitochondria:plasma membrane contacts between adjacent photoreceptor cells regulated by Opa1
• Three-dimensional structure of the basketweave Z-band in midshipman fish sonic muscle
• Endothelial MAPKs Direct ICAM-1 Signaling to Divergent Inflammatory Functions
• Correlative light and immuno-electron microscopy of retinal tissue cryostat sections.
• Oxidation of Atg3 and Atg7 mediates inhibition of autophagy.
• HtrA1 Mediated Intracellular Effects on Tubulin Using a Polarized RPE Disease Model.
• REEP6 deficiency leads to retinal degeneration through disruption of ER homeostasis and protein trafficking.
• Primary ciliary dyskinesia with normal ultrastructure: three-dimensional tomography detects absence of DNAH11.
• Primary Cilia Mediate Diverse Kinase Inhibitor Resistance Mechanisms in Cancer.
• Primary cilia mediate diverse kinase inhibitor resistance mechanisms in cancer
• Multivesicular Bodies: Roles in Intracellular and Intercellular Signaling
• Agonist binding affinity determines palmitoylation of the glucagon-like peptide-1 receptor and its functional interaction with plasma membrane nanodomains in pancreatic beta cells
• Phagosomal and mitochondrial alterations in RPE may contribute to KCNJ13 retinopathy.
• Selective Ablation of Megalin in the Retinal Pigment Epithelium Results in Megaophthalmos, Macromelanosome Formation and Severe Retina Degeneration.
• Mutations in Outer Dynein Arm Heavy Chain DNAH9 Cause Motile Cilia Defects and Situs Inversus.
• ALIX Regulates Tumor-Mediated Immunosuppression by Controlling EGFR Activity and PD-L1 Presentation.
• Symmetric arrangement of mitochondria:plasma membrane contacts between adjacent photoreceptor cells regulated by Opa1
• Agonist-induced membrane nanodomain clustering drives GLP-1 receptor responses in pancreatic beta cells
• Probing the Heterogeneity of Protein Kinase Activation in Cells by Super-Resolution Microscopy.
• Ciliary Feature Counter: A program for the Quantitative Assessment of Cilia to Diagnose Primary Ciliary Dyskinesia
• Membrane trafficking in the retinal pigment epithelium at a glance
• NPC1 regulates ER contacts with endocytic organelles to mediate cholesterol egress
• Zebrafish Motile Cilia as a Model for Primary Ciliary Dyskinesia
• Fission of megamitochondria into multiple smaller well-defined mitochondria in the ageing zebrafish retina
• Spillover events of rabbit haemorrhagic disease virus 2 (recombinant GI.4P‐GI.2) from Lagomorpha to Eurasian badger
• Glucose-dependent miR-125b is a negative regulator of β-cell function
• Visualization of cardiac muscle thin filaments and measurement of their lengths by electron tomography.
• Disruption of CFAP418 interaction with lipids causes abnormal membrane-associated cellular processes in retinal degenerations
• Functional Changes Within the Rod Inner Segment Ellipsoid in Wildtype Mice: An Optical Coherence Tomography and Electron Microscopy Study.
• A persistent neutrophil-associated immune signature characterises post-COVID19 pulmonary sequelae
• SPACA9 is a lumenal protein of human ciliary singlet and doublet microtubules
• Changes in Mitochondrial Size and Morphology in the RPE and Photoreceptors of the Developing and Ageing Zebrafish
• Arum Palaestinum with isovanillin, linolenic acid and beta-sitosterol inhibits prostate cancer spheroids and reduces the growth rate of prostate tumors in mice (vol 15, 264, 2015)
• KCNJ13-related energy crisis: Mitochondrial dynamics in the retinal degeneration zebrafish model
• Ultrastructural insight into SARS-CoV-2 entry and budding in human airway epithelium
• Use of electron tomography to confirm the diagnosis of primary ciliary dyskinesia
• Extracellular vesicles from monocyte/platelet aggregates modulate human atherosclerotic plaque reactivity
• Probing the Heterogeneity of Protein Kinase Activation in Cells by Super-resolution Microscopy
• Improving Primary Ciliary Dyskinesia diagnosis using Artificial Intelligence
• Tetherin antagonism by SARS-CoV-2 enhances virus release: multiple mechanisms including ORF3a-mediated defective retrograde traffic
• Axonemal structures reveal mechanoregulatory and disease mechanisms
• Developmental Expression of the Cell Cycle Regulator p16INK4a in Retinal Glial Cells: A Novel Marker for Immature Ocular Astrocytes?
• Loss of REP1 impacts choroidal melanogenesis in choroideremia
• Gold Particle Analyser: Detection and quantitative assessment of electron microscopy gold probes
• PCD-AID: artificial intelligence diagnosis of primary ciliary dyskinesia
• Combined approaches including long-read sequencing address the diagnostic challenge of HYDIN in primary ciliary dyskinesia
• Increasing the diagnostic yield in Primary Ciliary Dyskinesia via whole gene sequencing
• Utilising computer vision artificial intelligence to identify defects in airway ciliary motility and mucociliary clearance
• S83 Long-term effects of SARS-CoV-2 on ciliogenesis through altered expression of FOXJ1
• Disruption of CFAP418 interaction with lipids causes widespread abnormal membrane-associated cellular processes in retinal degenerations
• Primary Ciliary Dyskinesia and Retinitis Pigmentosa: Novel RPGR Variant and Possible Modifier Gene
• Daily Light Onset and Plasma Membrane Tethers Regulate Mitochondria Redistribution within the Retinal Pigment Epithelium
• Selective ablation of megalin in the retinal pigment epithelium results in megaophthalmos, macromelanosome formation and severe retina degeneration
• Increased transmission of SARS-CoV-2 lineage B.1.1.7 (VOC 2020212/01) is not accounted for by a replicative advantage in primary airway cells or antibody escape
• Symmetric arrangement of mitochondria:Plasma membrane contacts between adjacent photoreceptor cells regulated by opa1
• Phagosomal and mitochondrial alterations in RPE may contribute to KCNJ13 retinopathy
• HYDIN variants cause primary ciliary dyskinesia in the Finnish population
• Rescue of cone and rod photoreceptor function in a CDHR1-model of age-related retinal degeneration
• Spillover events of rabbit haemorrhagic disease virus 2 (recombinant GI.4P-GI.2) from Lagomorpha to Eurasian badger
• Combined approaches, including long-read sequencing, address the diagnostic challenge of HYDIN in primary ciliary dyskinesia
• A persistent neutrophil-associated immune signature characterizes post-COVID-19 pulmonary sequelae
• PCD Detect: Enhancing ciliary features through image averaging and classification
• Physiological and pathophysiological aspects of primary cilia—a literature review with view on functional and structural relationships in cartilage
• Ciliary feature counter: A program for the quantitative assessment of cilia to diagnose primary ciliary dyskinesia
• Age-specific nasal epithelial responses to SARS-CoV-2 infection
• Ultrastructural insight into SARS-CoV-2 attachment, entry and budding in human airway epithelium
• AMP-activated protein kinase is a key regulator of acute neurovascular permeability
• Immunobiology of a rationally-designed AAV2 capsid following intravitreal delivery in mice
• Chronically shortened rod outer segments accompany photoreceptor cell death in Choroideremia
• Remodeling of the basal labyrinth of retinal pigment epithelial cells with osmotic challenge, age, and disease
• Loss of REP1 impacts choroidal melanogenesis and vasculogenesis in choroideremia
• Automated Segmentation of Mitochondria in Virus-Infected Cells Using Deep Learning Models
• Glucose-Dependent miR-125b Is a Negative Regulator of β-Cell Function
• HYDIN variants cause primary ciliary dyskinesia in the Finnish population
• Zebrafish motile cilia as a model for primary ciliary dyskinesia
• Correction to: Age-specific nasal epithelial responses to SARS-CoV-2 infection (Nature Microbiology, (2024), 9, 5, (1293-1311), 10.1038/s41564-024-01658-1)
• Erratum: Functional Changes Within the Rod Inner Segment Ellipsoid in Wildtype Mice: An Optical Coherence Tomography and Electron Microscopy Study (Invest Ophthalmol Vis Sci. (2022) 63:8 DOI: 10.1167/iovs.63.8.8)
• Developmental Expression of the Cell Cycle Regulator p16INK4a in Retinal Glial Cells: A Novel Marker for Immature Ocular Astrocytes?
• Ua-zero as a uranyl acetate replacement when diagnosing primary ciliary dyskinesia by transmission electron microscopy
• The emergence of goblet inflammatory or ITGB6hi nasal progenitor cells determines age-associated SARS-CoV-2 pathogenesis
• Impaired Lysosome Reformation in Chloroquine-Treated Retinal Pigment Epithelial Cells
• Tetherin antagonism by SARS-CoV-2 ORF3a and spike protein enhances virus release
• Targeted NGS gene panel identifies mutations in RSPH1 causing primary ciliary dyskinesia and a common mechanism for ciliary central pair agenesis due to radial spoke defects
• Phenotypic variability of CCDC103 mutation in British Pakistani children with Primary Ciliary Dyskinesia (PCD)
• Recessive HYDIN mutations cause primary ciliary dyskinesia without randomization of left-right body asymmetry
• New light on photoreceptor renewal
• Correlative light and immuno-electron microscopy of retinal tissue cryostat sections
• Characterizing the ultrastructure of primary ciliary dyskinesia transposition defect using electron tomography
• Visualization of cardiac muscle thin filaments and measurement of their lengths by electron tomography
• Retinal pigment epithelial cells mitigate the effects of complement attack by endocytosis of C5b-9
• Endothelial MAPKs direct ICAM-1 signaling to divergent inflammatory functions
• Calcium signaling at ER membrane contact sites
• Differential apicobasal VEGF signaling at vascular blood-neural barriers
• CCDC151 mutations cause primary ciliary dyskinesia by disruption of the outer dynein arm docking complex formation
• Methamphetamine-induced nitric oxide promotes vesicular transport in blood-brain barrier endothelial cells
• Mutations in Outer Dynein Arm Heavy Chain DNAH9 Cause Motile Cilia Defects and Situs Inversus
• ALIX Regulates Tumor-Mediated Immunosuppression by Controlling EGFR Activity and PD-L1 Presentation
• Regulation of melanosome number, shape and movement in the zebrafish retinal pigment epithelium by OA1 and PMEL
• Mutations in REEP6 Cause Autosomal-Recessive Retinitis Pigmentosa
• Primary ciliary dyskinesia with normal ultrastructure: Three-dimensional tomography detects absence of DNAH11
• Generation of a three-dimensional ultrastructural model of human respiratory cilia
• HtrA1 Mediated Intracellular Effects on Tubulin Using a Polarized RPE Disease Model
• REEP6 deficiency leads to retinal degeneration through disruption of ER homeostasis and protein trafficking
• Gene discovery for motile cilia disorders: Mutation spectrum in primary ciliary dyskinesia and discovery of mutations in CCDC151
• Oxidation of Atg3 and Atg7 mediates inhibition of autophagy
• Primary Cilia Mediate Diverse Kinase Inhibitor Resistance Mechanisms in Cancer
• The relationship between ER - Multivesicular body membrane contacts and the ESCRT machinery
• Expression of OA1 limits the fusion of a subset of MVBs with lysosomes - A mechanism potentially involved in the initial biogenesis of melanosomes
• Expression of OA1 limits the fusion of a subset of MVBs with lysosomes - a mechanism potentially involved in the initial biogenesis of melanosomes [J. Cell Sci. 126, 5143-5152]
• Identification of ER:melanosome membrane contact sites in the retinal pigment epithelium.
• Identification of ER:melanosome membrane contact sites in the retinal pigment epithelium
• Activation of proresolving macrophages in dorsal root ganglia attenuates persistent arthritis pain