Thomas Burgoyne

Publications

  • New light on photoreceptor renewal.
  • PCD Detect: enhancing ciliary features through image averaging and classification
  • Physiological and Pathophysiological Aspects of Primary Cilia—A Literature Review with View on Functional and Structural Relationships in Cartilage
  • A Comparison Between Chlamydomonas Flagella And Human Cilia By Electron Tomography
  • WASH and Tsg101/ALIX-dependent diversion of stress-internalized EGFR from the canonical endocytic pathway
  • The relationship between ER–multivesicular body membrane contacts and the ESCRT machinery
  • The Study Of Primary Ciliary Dyskinesia In Difficult Cases Using Electron Tomography
  • Retinal Pigment Epithelial Cells Mitigate the Effects of Complement Attack by Endocytosis of C5b-9.
  • Three-Dimensional Structure of Vertebrate Muscle Z-Band: The Small-Square Lattice Z-Band in Rat Cardiac Muscle
  • Methamphetamine-induced nitric oxide promotes vesicular transport in blood–brain barrier endothelial cells
  • Differential Apicobasal VEGF Signaling at Vascular Blood-Neural Barriers
  • Generation of a Three-Dimensional Ultrastructural Model of Human Respiratory Cilia
  • Rod disc renewal occurs by evagination of the ciliary plasma membrane that makes cadherin-based contacts with the inner segment
  • Phenotypic variability of CCDC103 mutation in British Pakistani children with Primary Ciliary Dyskinesia (PCD).
  • Gene discovery for motile cilia disorders: mutation spectrum in primary ciliary dyskinesia and discovery of mutations in CCDC151.
  • Regulation of melanosome number, shape and movement in the zebrafish retinal pigment epithelium by OA1 and PMEL.
  • Calcium signaling at ER membrane contact sites.
  • CCDC151 mutations cause primary ciliary dyskinesia by disruption of the outer dynein arm docking complex formation.
  • Characterizing the ultrastructure of primary ciliary dyskinesia transposition defect using electron tomography.
  • Targeted NGS gene panel identifies mutations in RSPH1 causing primary ciliary dyskinesia and a common mechanism for ciliary central pair agenesis due to radial spoke defects.
  • Expression of OA1 limits the fusion of a subset of MVBs with lysosomes - a mechanism potentially involved in the initial biogenesis of melanosomes.
  • Three dimensional ultrastructure of human respiratory cilia in health and disease.
  • Recessive HYDIN mutations cause primary ciliary dyskinesia without randomization of left-right body asymmetry.
  • Mutations in REEP6 Cause Autosomal-Recessive Retinitis Pigmentosa.
  • Symmetric arrangement of mitochondria:plasma membrane contacts between adjacent photoreceptor cells regulated by Opa1
  • Three-dimensional structure of the basketweave Z-band in midshipman fish sonic muscle
  • Endothelial MAPKs Direct ICAM-1 Signaling to Divergent Inflammatory Functions
  • Correlative light and immuno-electron microscopy of retinal tissue cryostat sections.
  • Oxidation of Atg3 and Atg7 mediates inhibition of autophagy.
  • HtrA1 Mediated Intracellular Effects on Tubulin Using a Polarized RPE Disease Model.
  • REEP6 deficiency leads to retinal degeneration through disruption of ER homeostasis and protein trafficking.
  • Primary ciliary dyskinesia with normal ultrastructure: three-dimensional tomography detects absence of DNAH11.
  • Primary Cilia Mediate Diverse Kinase Inhibitor Resistance Mechanisms in Cancer.
  • Primary cilia mediate diverse kinase inhibitor resistance mechanisms in cancer
  • Multivesicular Bodies: Roles in Intracellular and Intercellular Signaling
  • Agonist binding affinity determines palmitoylation of the glucagon-like peptide-1 receptor and its functional interaction with plasma membrane nanodomains in pancreatic beta cells
  • Phagosomal and mitochondrial alterations in RPE may contribute to KCNJ13 retinopathy.
  • Selective Ablation of Megalin in the Retinal Pigment Epithelium Results in Megaophthalmos, Macromelanosome Formation and Severe Retina Degeneration.
  • Mutations in Outer Dynein Arm Heavy Chain DNAH9 Cause Motile Cilia Defects and Situs Inversus.
  • ALIX Regulates Tumor-Mediated Immunosuppression by Controlling EGFR Activity and PD-L1 Presentation.
  • Symmetric arrangement of mitochondria:plasma membrane contacts between adjacent photoreceptor cells regulated by Opa1
  • Agonist-induced membrane nanodomain clustering drives GLP-1 receptor responses in pancreatic beta cells
  • Probing the Heterogeneity of Protein Kinase Activation in Cells by Super-Resolution Microscopy.
  • Ciliary Feature Counter: A program for the Quantitative Assessment of Cilia to Diagnose Primary Ciliary Dyskinesia
  • Membrane trafficking in the retinal pigment epithelium at a glance
  • NPC1 regulates ER contacts with endocytic organelles to mediate cholesterol egress
  • Zebrafish Motile Cilia as a Model for Primary Ciliary Dyskinesia
  • Fission of megamitochondria into multiple smaller well-defined mitochondria in the ageing zebrafish retina
  • Spillover events of rabbit haemorrhagic disease virus 2 (recombinant GI.4P‐GI.2) from Lagomorpha to Eurasian badger
  • Glucose-dependent miR-125b is a negative regulator of β-cell function
  • Visualization of cardiac muscle thin filaments and measurement of their lengths by electron tomography.
  • Disruption of CFAP418 interaction with lipids causes abnormal membrane-associated cellular processes in retinal degenerations
  • Functional Changes Within the Rod Inner Segment Ellipsoid in Wildtype Mice: An Optical Coherence Tomography and Electron Microscopy Study.
  • A persistent neutrophil-associated immune signature characterises post-COVID19 pulmonary sequelae
  • SPACA9 is a lumenal protein of human ciliary singlet and doublet microtubules
  • Changes in Mitochondrial Size and Morphology in the RPE and Photoreceptors of the Developing and Ageing Zebrafish
  • Arum Palaestinum with isovanillin, linolenic acid and beta-sitosterol inhibits prostate cancer spheroids and reduces the growth rate of prostate tumors in mice (vol 15, 264, 2015)
  • KCNJ13-related energy crisis: Mitochondrial dynamics in the retinal degeneration zebrafish model
  • Ultrastructural insight into SARS-CoV-2 entry and budding in human airway epithelium
  • Use of electron tomography to confirm the diagnosis of primary ciliary dyskinesia
  • Extracellular vesicles from monocyte/platelet aggregates modulate human atherosclerotic plaque reactivity
  • Probing the Heterogeneity of Protein Kinase Activation in Cells by Super-resolution Microscopy
  • Improving Primary Ciliary Dyskinesia diagnosis using Artificial Intelligence

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