Trial Name|Organisation Name|Is a CTU involved in the trial?|Is this a feasibility trial?|ISRCTN|Trial Status|Type of Randomisation|Trial Design|Type of Blinding|Trial Setting|Type of Intervention|Study population|Disease Area|Disease Category|Total Trial size: Total number of participants|Trial Size: Number of UK participants|Actual or Target trial size?|Recruitment Start |Recruitment Stop|Intervention Arm|Control Arm|Primary Outcome Measure|Primary Outcome Type|Reason for RCHD access, collected from publically available documentation (long form) [text from protocols or publications unless stated in square brackets]|Reason for RCHD access, collected from publically available documentation (short form)|Reason for RCHD access on registry access log|RCHD Registry Used|Date of RCHD access form|Trial Size RIGHT|University of Nottingham|No|Yes|ISRCTN66434824|Completed|Individual|Treatment|Patients only|Primary care|Drug intervention|40yrs+ with recent onset stroke and SBP >140 mmHg|Stroke|Cardiovascular and stroke|41|41|Actual|2010|2011|Transdermal glyceryl trinitrate (GTN; 5 mg/24 hours)|Placebo|Feasibility|Clinical|Unclear|Unclear|Unclear|NHS-D|14-May-19|1-500 PODCAST|University of Nottingham|No|Yes|ISRCTN85562386|Completed|Individual|Treatment|Open|Secondary care|Other|Recent stroke|Stroke|Cardiovascular and stroke|83|83|Actual|2010|2014|At least 6 months of intensive (target SBP <125 mmHg)|Guideline (target SBP <140 mmHg) BP lowering|Feasibility|Clinical|[There is no information in the protocol or results pages indicating the use of RCHD]|Unclear|Unclear|ISD/eDRIS|17-Apr-19|1-500 UKLS|University of Liverpool|Yes|Yes|ISRCTN78513845|Completed|Individual|Screening|Open|Secondary care|Other|Men and women aged 50-75|Lung cancer|Cancer|4061|4061|Actual|2011|2012|CT scan|No CT scan|Feasibility|Administrative|All participants randomised onto the UKLS trial will be registered with either the National Health Service Central Register for England and Wales (ONS) or the Cancer Registry. The computerised randomisation for each subject at the registry will be tagged for prompt notification to the study directors in the event of new cases of cancer and deaths from cancer in the study population. The registry will also notify the LCTU of individual subjects who do not appear on the register so that further information required to trace their entry, can be obtained or alternative methods of follow up can be employed.|Cancer and Death|Adverse Events|NHS-D/HSCIC |19-Feb-19|500-5000 VIDAL|London School of Hygiene and Tropical Medicine|No|Yes|ISRCTN46328341|Completed|Cluster randomized comparison|Primary Prevention|Patients and research staff|Primary care (GP practices)|Drug intervention|Elderly|Mortality|Nutritional, Metabolic, Endocrine|1615 over 20 registerered GP Practices|1615|Actual|2012|2013|Vitamin D oil|Placebo/no intervention|Feasibility|Administrative|Hospital attendances, cancer diagnoses and deaths were ascertained by linkage to Hospital Episode Statistics and national registration through NHS Digital.|Hospital attendances, cancer diagnoses and deaths |Adverse Events|NHS-D/HSCIC |18-Dec-18|500-5000 HITS-NS|University of Manchester|No|Yes|ISRCTN68087745|Completed|Cluster|Treatment|Patients only|Primary care|Other|Injured patients >= 16 years with TBI but stable|Neurosurgery|Other|293|293|Actual|2012|2013|Direct transport to the nearest neuroscience centres|Transport to non-specialist acute hospital|Feasibility|Administrative|Daily screening of the AS patient report forms using electronic databases'. Screening patients who had been given 'trauma pre alerts' or the words head injury were written on the ambulance report (Patient Report Form)|Recruitment|Recruitment|TARN|30-Jun-19|1-500 PATHFINDER|Welsh Ambulance Services NHS Trust|Unclear|Yes|ISRCTN98216498|Completed|Cluster|Treatment|Research staff only|Primary care|Drug intervention|Adults with opioid overdose and mental capacity|Opioid overdose|Mental health|100|100|Target|2012|2017|Offer Take Home Naloxone (THN) kits to fully recovered, consenting patient|No provision of THN kit|Feasibility|Administrative|We will follow-up ED contacts, hospital admissions and mortality at 12 months through anonymised linked data via the SAIL Databank|Follow-up, hospital admissions and mortality|Follow up|SAIL|30-Jun-19|1-500 REACH|University of Leeds|Yes|Yes|ISRCTN16076575|Completed|Cluster|Primary Prevention|Research staff only|Secondary care|Other|Elderly in care homes|Other (wellbeing)|Other|120|120|Target|2015|2017|REACH intervention plus usual care|Usual care|Feasibility|Administrative|Adverse event data will be collected by a researcher on a monthly basis and the best method of collecting service use data will be explored, including data routinely recorded by the care home as well as, where possible, via receipt of hospital attendance data from NHS Digital and relevant Acute Hospital Trusts.|Service use data e.g. hospital attendence|Adverse Events|NHS-D/HSCIC |05-Mar-19|Unclear ACT|University of Edinburgh|No|Yes|Not Applicable (PhD)|Completed|Individual|Treatment|Research staff only|Primary care|Other|Anxiety and Depression|Anxiety and Depression|Mental health|52|52|Target|2015|2017|Self-help manual|Usual care|Quality of life|Clinical|Recruitment|Recruitment|Recruitment|ISD/eDRIS|09-Jul-19|1-500 TIER|Swansea University Medical School|Yes|Yes|ISRCTN85516498|Completed|Cluster|Treatment|Open|Secondary care|Other|Low-risk suspected transient ischaemic attack|Stroke|Cardiovascular and stroke|53|53|Actual|2015|2017|Complex package|Usual care|Subsequent emergency contact|Clinical|During the period of patient recruitment, some of the clinicians and managers in the study area are interviewed to get their opinions and ensure there are no concerns with safety. Using the secure anonymised information linkage databank (SAIL), what happens to the participating patients (in either group) are tracked. |Full trial data|Follow up|SAIL|29-Apr-19|1-500 FISH|Imperial College Healthcare NHS Trust|Yes|Yes|ISRCTN15244462|Completed|Individual|Treatment|Open|Secondary care|Other|Infection with shock at 37 weeks to 16 years|Paediatric infection|Infection|75|75|Actual|2016|2017|Fluid bolus volume (10mL/kg|Fluid bolus volume (20mL/kg)|Feasibility|Administrative|"For participants admitted to PICU, daily organ support data were obtained via linkage with the Paediatric Intensive Care Audit Network, the UK national clinical audit for paediatric intensive care. In protocol: ""routine linkage will be used as applicable, e.g. with PICANet and the Health & Social Care Information Centre (HSCIC)."""|Data collection|Data collection|PICANET|30-Jun-19|1-500 SAFE|University of Liverpool|Yes|Yes|ISRCTN13871327|Completed|Individual|Treatment|Open|Secondary care|Other|Adults with epilepsy|Seizures|Mental health|58|58|Actual|2016|2016|Seizure First Aid Training course|No training|A&E attendance for epilepsy|Clinical|3. Proposed primary outcome measure: The number of epilepsy-related emergency department (ED) visits made over the 12 months following randomisation by patient participant. This will be measured using routinely collected NHS data. The Hospital Episode Statistics (HES) system provides a central record of an individual?s use of all EDs in England and data will be extracted from this system (using participants? NHS numbers) to provide information on individual participants? use of ED at baseline and over the 12 months of follow-up. HES data will be requested at the start of Project Month 32 in a single tranche.|Primary outcome data|Data collection|NHS-D/HSCIC |03-Apr-19|1-500 PERFECTED-ER|University of East Anglia|Yes|Yes|ISRCTN99336264|Completed|Cluster|Treatment|Open|Secondary care|Other|Patients with dementia who break their hip|Dementia|Mental health|282|282|Actual|2016|2018|Multicomponent PERFECTED enhanced recovery intervention|Usual care|Feasibility|Administrative|We will collect hospital care data (Accident and Emergency visits, inpatient and day-case admissions, outpatient appointments) from the clinical records of the participating NHS Trusts|Hospital care data|Follow up|NHFD|20-May-19|1-500 FEVER|Intensive Care National Audit and Research Centre|Yes|Yes|ISRCTN16022198|Completed|Individual|Treatment|Open|Secondary care|Other|Children on PICU with infection causing fever|Paediatric infection|Infection|100|100|Actual|2017|2017|Permissive temperature threshold (39.5C)|Restrictive temperature threshold (37.5C)|Recruitment and retention rates, protocol adherence and separation between groups and distribution of potential outcomes|Administrative|[Possibly general data collection but not clear]|Unclear|Data collection|PICANET|10-Jun-19|1-500 PHRASE|Swansea University Medical School|Yes|Yes|ISRCTN36856873|Completed|Individual|Treatment|Open|Secondary care|Other|Suspected of having severe ""Red Flag"" sepsis|Sepsis|Infection|100|100|Target|2017|2018|Enhanced care|Usual care|Feasibility|Administrative|Patients will be followed up at 90 days using linked anonymised data to capture length of hospital admission and mortality.|Hospital admission and mortality|Follow up|SAIL|29-Apr-19|1-500 WHEAT|Imperial College London|Yes|Yes|ISRCTN62501859|Completed|Individual|Treatment|Open|Secondary care|Other|Premature babies|Enterocolitis|Pregnancy and childbirth|250|250|Target|2018|2020|Withhold feeds around transfusion|Continue feeds around transfusion|Feasibility|Administrative|All trial data will be obtained from an existing research database, the National Neonatal Research Database (NNRD). This holds patient level clinical data from 2007 to the present extracted quarterly from the electronic health record of all admissions to NHS neonatal units in England and Wales. Data items are a NHS Information Standard and appropriate approvals are held. NNRD data has been validated against clinical trial data and patient notes. During the WHEAT trial, key data items (allocation and outcome data) will be validated by local clinicians using an established national system|Data collection|Data collection|NNRD at NDAU|11-Apr-19|1-500